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Article

A size threshold limits prion transmission and establishes phenotypic diversity.

Science (New York, N.Y.) - 29 Oct 2010

Derdowski Aaron, Sindi Suzanne S, Klaips Courtney L, DiSalvo Susanne, Serio Tricia R

Abstract excerpt

According to the prion hypothesis, atypical phenotypes arise when a prion protein adopts an alternative conformation and persist when that form assembles into self-replicating aggregates. Amyloid formation in vitro provides a model for this protein-misfolding pathway, but the mechanism by which this process interacts with the cellular environment to produce transmissible phenotypes is poorly understood. Using the...

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Identifiers

PMID: 21030659
DOI: 10.1126/science.1197785
PMCID: PMC3003433

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