Article
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.
The Journal of biological chemistry - 16 Sept 2005
Alderwick Luke J, Radmacher Eva, Seidel Mathias, Gande Roland, Hitchen Paul G, Morris Howard R, Dell Anne, Sahm Hermann, Eggeling Lothar, Besra Gurdyal S
Abstract excerpt
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic acids connected to peptidoglycan via arabinogalactan (AG) and abbreviated as the mAGP complex. The mAGP complex is crucial for the survival and pathogenicity of M. tuberculosis and is the target of several anti-tubercular agents. Apart from sharing a similar mAGP and the availability of the complete genome sequence,...
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