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Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study.

Diabetes care - 1 Feb 2011

Uusitupa Matti I, Stancáková Alena, Peltonen Markku, Eriksson Johan G, Lindström Jaana, Aunola Sirkka, Ilanne-Parikka Pirjo, Keinänen-Kiukaanniemi Sirkka, Tuomilehto Jaakko, Laakso Markku

Abstract excerpt

OBJECTIVE: We aimed to investigate the influence of positive family history (FH+) of diabetes and 19 known genetic risk loci on the effectiveness of lifestyle changes and their predictive value on the incidence of type 2 diabetes in the Finnish Diabetes Prevention Study (DPS). RESEARCH DESIGN AND METHODS: A total of 522 subjects with impaired glucose tolerance (IGT) were randomized into the control (n = 257) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20980412
DOI: 10.2337/dc10-1013
PMCID: PMC3024360

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