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Article

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway.

American journal of physiology. Endocrinology and metabolism - 1 Jan 2011

Xin Xiaoban, Zhou Lijun, Reyes Caleb M, Liu Feng, Dong Lily Q

Abstract excerpt

The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear. Here we show that, in C(2)C(12) cells, overexpression or suppression of APPL1 enhanced or suppressed, respectively, adiponectin-stimulated p38 MAPK upstream kinase cascade, consisting of transforming growth factor-β-activated kinase 1...

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Identifiers

PMID: 20978232
DOI: 10.1152/ajpendo.00427.2010
PMCID: PMC3023211

Genes

APPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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