Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Truncation of PITX2 differentially affects its activity on physiological targets.

Journal of molecular endocrinology - 1 Feb 2011

Quentien Marie-Hélène, Vieira Véronique, Menasche Maurice, Dufier Jean-Louis, Herman Jean-Paul, Enjalbert Alain, Abitbol Marc, Brue Thierry

Abstract excerpt

The bicoid-like transcription factor PITX2 has been previously described to interact with the pituitary-specific POU homeodomain factor POU1F1 (human ortholog of PIT-1) to achieve cell-specific expression of prolactin (PRL) and GH in pituitary somatolactotroph cells. In this work, we have investigated the functional properties of three PITX2 mutants reported in Axenfeld-Rieger syndrome patients relative to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anterior Eye Segment
Share to Eye Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Diseases, Hereditary

Share to Homeobox Protein PITX2

Share to Human Growth Hormone

Share to Pituitary Gland

Share to Prolactin

Share to Transcription Factor Pit-1

Source

Identifiers

PMID: 20978111
DOI: 10.1677/JME-10-0063

Genes

PITX2
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncation of PITX2 differentially affects its activity on physiological targets.PMID 20978111Read ↗

An unusual class of PITX2 mutations in Axenfeld-Rieger syndrome.Semantic proximity Read ↗

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities.Semantic proximity Read ↗

PITX genes are required for cell survival and Lhx3 activation.Semantic proximity Read ↗

Identification of a dominant negative homeodomain mutation in Rieger syndrome.Semantic proximity Read ↗

Pitx2is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specificationSemantic proximity Read ↗

Functional characterization of a human <i>POU1F1</i> mutation associated with isolated growth hormone deficiency: a novel etiology for IGHDSemantic proximity Read ↗

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.Semantic proximity Read ↗

PIT1 abnormality.Semantic proximity Read ↗

Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.Semantic proximity Read ↗

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.Semantic proximity Read ↗

Functional analyses of two newly identified PITX2 mutants reveal a novel molecular mechanism for Axenfeld-Rieger syndrome.Semantic proximity Read ↗

Pituitary transcription factors: from congenital deficiencies to gene therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.