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Article

Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.

Physiological genomics - 1 Jan 2011

Tian Jing, Fratz Sohrab, Hou Yali, Lu Qing, Görlach Agnes, Hess John, Schreiber Christian, Datar Sanjeev A, Oishi Peter, Nechtman John, Podolsky Robert, She Jin-Xiong, Fineman Jeffrey R, Black Stephen M

Abstract excerpt

Disordered angiogenesis is implicated in pulmonary vascular remodeling secondary to congenital heart diseases (CHD). However, the underlying genes are not well delineated. We showed previously that an ovine model of CHD with increased pulmonary blood flow (PBF, Shunt) has an "angiogenesis burst" between 1 and 4 wk of age. Thus we hypothesized that the increased PBF elicited a proangiogenic gene expression profile...

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Identifiers

PMID: 20978110
DOI: 10.1152/physiolgenomics.00135.2010
PMCID: PMC3026563

Genes

FGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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