Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis.

doi:10.1053/j.gastro.2010.10.045

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Article

Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis.

Gastroenterology - 1 Jan 2011

Schneider Alexander, Larusch Jessica, Sun Xiumei, Aloe Amy, Lamb Janette, Hawes Robert, Cotton Peter, Brand Randall E, Anderson Michelle A, Money Mary E, Banks Peter A, Lewis Michele D, Baillie John, Sherman Stuart, Disario James, Burton Frank R, Gardner Timothy B, Amann Stephen T, Gelrud Andres, George Ryan, Rockacy Matthew J, Kassabian Sirvart, Martinson Jeremy, Slivka Adam, Yadav Dhiraj, Oruc Nevin, Barmada M Michael, Frizzell Raymond, Whitcomb David C

Abstract excerpt

BACKGROUND & AIMS: Idiopathic chronic pancreatitis (ICP) is a complex inflammatory disorder associated with multiple genetic and environmental factors. In individuals without cystic fibrosis (CF), variants of CFTR that inhibit bicarbonate conductance but maintain chloride conductance might select...

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Identifiers

PMID: 20977904
DOI: 10.1053/j.gastro.2010.10.045
PMCID: PMC3171690

Genes

CFTR
SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20977904-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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