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Three Epigenetic Biomarkers, <i>GDF15</i> , <i>TMEFF2</i> , and <i>VIM</i> , Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

26 Oct 2010

Abstract excerpt

PURPOSE: To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments. EXPERIMENTAL DESIGN: Gene expression microarray analysis of BlCa cell lines treated with 5-aza-2'-deoxycytidine and trichostatin A as well as 26 tissue samples was used to identify a list of novel methylation candidates for BlCa. Methylation levels of candidate genes were quantified in 4 BlCa...

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PMID: 20975101
DOI: 10.1158/1078-0432.ccr-10-1312

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