Article
Water's role in the force-induced unfolding of ubiquitin.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2010
Li Jingyuan, Fernandez Julio M, Berne B J
Abstract excerpt
In atomic force spectroscopic studies of the elastomeric protein ubiquitin, the β-strands 1-5 serve as the force clamp. Simulations show how the rupture force in the force-induced unfolding depends on the kinetics of water molecule insertion into positions where they can eventually form hydrogen...
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