Article
Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?
Genetics, selection, evolution : GSE - 22 Oct 2010
Cierco-Ayrolles Christine, Dejean Sébastien, Legarra Andrés, Gilbert Hélène, Druet Tom, Ytournel Florence, Estivals Delphine, Oumouhou Naïma, Mangin Brigitte
Abstract excerpt
BACKGROUND: Since 2001, the use of more and more dense maps has made researchers aware that combining linkage and linkage disequilibrium enhances the feasibility of fine-mapping genes of interest. So, various method types have been derived to include concepts of population genetics in the analyses. One major drawback of many of these methods is their computational cost, which is very significant when many markers...
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