Article
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.
The EMBO journal - 1 Dec 2010
Ren Min, Guo Qing, Guo Liang, Lenz Martin, Qian Feng, Koenen Rory R, Xu Hua, Schilling Alexander B, Weber Christian, Ye Richard D, Dinner Aaron R, Tang Wei-Jen
Abstract excerpt
Macrophage inflammatory protein-1 (MIP-1), MIP-1α (CCL3) and MIP-1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1α and MIP-1β form high-molecular-weight aggregates. Our crystal structures reveal that MIP-1 aggregation is a polymerization process and human MIP-1α and MIP-1β form rod-shaped, double-helical polymers. Biophysical analyses and mathematical modelling...
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