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Article

Locus assignment of human alpha globin mutations by selective amplification and direct sequencing.

British journal of haematology - 1 Oct 1990

Dodé C, Rochette J, Krishnamoorthy R

Abstract excerpt

We describe a simple approach for molecular characterization and locus assignment of structural mutants by direct sequencing of enzymatically amplified DNA selective to alpha 1 and alpha 2 globin gene regions. Nucleotide substitution of two structural variants (Stanleyville II alpha 2(78Lys) and J Mexico alpha 2(54Glu) were determined and their encoding loci were specified. The amplified segment encompasses...

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PMID: 2094330
DOI: 10.1111/j.1365-2141.1990.tb07884.x

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