Locus assignment of human alpha globin mutations by selective amplification and direct sequencing.

doi:10.1111/j.1365-2141.1990.tb07884.x

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Article

Locus assignment of human alpha globin mutations by selective amplification and direct sequencing.

British journal of haematology - 1 Oct 1990

Dodé C, Rochette J, Krishnamoorthy R

Abstract excerpt

We describe a simple approach for molecular characterization and locus assignment of structural mutants by direct sequencing of enzymatically amplified DNA selective to alpha 1 and alpha 2 globin gene regions. Nucleotide substitution of two structural variants (Stanleyville II alpha 2(78Lys) and...

Topics

Africa
Base Sequence
Black People
DNA
France
Genetic Variation
Globins
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Amplification Techniques
Oligonucleotide Probes
Restriction Mapping

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