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Article

Sequence variations of the alpha-globin genes: scanning of high CG content genes with DHPLC and DG-DGGE.

Human mutation - 1 Oct 2004

Lacerra Giuseppina, Fiorito Mirella, Musollino Gennaro, Di Noce Francesca, Esposito Maria, Nigro Vincenzo, Gaudiano Carlo, Carestia Clementina

Abstract excerpt

The alpha-globin chains are encoded by two duplicated genes (HBA2 and HBA1, 5'-3') showing overall sequence homology >96% and average CG content >60%. alpha-Thalassemia, the most prevalent worldwide autosomal recessive disorder, is a hereditary anemia caused by sequence variations of these genes in about 25% of carriers. We evaluated the overall sensitivity and suitability of DHPLC and DG-DGGE in scanning both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15365991
DOI: 10.1002/humu.20088

Genes

HBA2
HBA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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