Article
Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets.
CNS & neurological disorders drug targets - 1 Dec 2010
Bosco Daryl A, Landers John E
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is an incurable disease resulting from the deterioration of motor neurons. The onset of disease typically occurs in the fifth decade of life and progresses rapidly; death occurs for 75% of patients within 5 years. The only drug that is available to treat ALS is riluzole, which extends survival by just 2-3 months. Thus, new therapeutic directions are being sought to prolong the...
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