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Article

Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.

Human reproduction (Oxford, England) - 1 Dec 2010

Gu Aihua, Ji Guixiang, Shi Xiangguo, Long Yan, Xia Yankai, Song Ling, Wang Shoulin, Wang Xinru

Abstract excerpt

BACKGROUND: The Piwi subfamily of genes is involved in spermatogenesis for the maintenance and meiosis of germline stem cells. Mice bearing targeted mutations in Piwi genes (Miwi, Mili and Miwi2) are sterile with distinct defects in spermatogenesis. We hypothesized that Piwi gene polymorphisms could be a risk factor for spermatogenic failure. METHODS: For this study, 490 patients with idiopathic azoospermia or...

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Source

Identifiers

PMID: 20940137
DOI: 10.1093/humrep/deq274

Genes

PIWIL1
PIWIL2
PIWIL3
PIWIL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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