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Article

Underexposed polar residues and protein stabilization.

Protein engineering, design & selection : PEDS - 1 Jan 2011

Ayuso-Tejedor Sara, Abián Olga, Sancho Javier

Abstract excerpt

Increasing protein stability is interesting for practical reasons and because it tests our understanding of protein energetics. We explore here the feasibility of stabilizing proteins by replacing underexposed polar residues by apolar ones of similar size and shape. We have compared the stability of wild-type apoflavodoxin with that of a few carefully selected mutants carrying Y → F, Q → L, T → V or K → M...

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Identifiers

PMID: 20937603
DOI: 10.1093/protein/gzq072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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