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Article

Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfaces.

BMC bioinformatics - 21 Oct 2008

Bougouffa Salim, Warwicker Jim

Abstract excerpt

BACKGROUND: Empirical binding models have previously been investigated for the energetics of protein complexation (DeltaG models) and for the influence of mutations on complexation (i.e. differences between wild-type and mutant complexes, DeltaDeltaG models). We construct binding models to directly compare these processes, which have generally been studied separately. RESULTS: Although reasonable fit models were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18939984
DOI: 10.1186/1471-2105-9-448
PMCID: PMC2596146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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