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Epigenetic reprogramming in somatic cells induced by extract from germinal vesicle stage pig oocytes

6 Nov 2012

Abstract excerpt

Genomic reprogramming factors in the cytoplasm of germinal vesicle (GV) stage oocytes have been shown to improve the efficiency of producing cloned mouse offspring through the exposure of nuclei to a GV cytoplasmic extract prior to somatic cell nuclear transfer (SCNT) to enucleated oocytes. Here, we developed an extract of GV stage pig oocytes (GVcyto-extract) to investigate epigenetic reprogramming events in...

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PMID: 23132243
DOI: 10.1242/dev.086116

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