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Interferon Alpha Induces Establishment of Alphaherpesvirus Latency in Sensory Neurons In Vitro

29 Sept 2010

Abstract excerpt

BACKGROUND: Several alphaherpesviruses, including herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), establish lifelong latency in neurons of the trigeminal ganglion (TG). Although it is thought that efficient establishment of alphaherpesvirus latency is based on a subtle interplay between virus, neurons and the immune system, it is not clear which immune components are of major importance for the...

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PMID: 20927329
DOI: 10.1371/journal.pone.0013076

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