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Article

Mitochondrial localization and regulation of BRAFV600E in thyroid cancer: a clinically used RAF inhibitor is unable to block the mitochondrial activities of BRAFV600E.

The Journal of clinical endocrinology and metabolism - 1 Jan 2011

Lee Min Hee, Lee Seong Eun, Kim Dong Wook, Ryu Min Jeong, Kim Sung Jin, Kim Sung Joong, Kim Yong Kyoung, Park Ji Hoon, Kweon Gi Ryang, Kim Jin Man, Lee Jung Uee, De Falco Valentina, Jo Young Suk, Shong Minho

Abstract excerpt

CONTEXT: The oncogenic BRAF(V600E) mutation results in an active structural conformation characterized by greatly elevated ERK activity. However, additional cellular effects caused by subcellular action of BRAF(V600E) remain to be identified. OBJECTIVE: To explore these effects, differences in th...

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Identifiers

PMID: 20926530
DOI: 10.1210/jc.2010-1071

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20926530-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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