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Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim

27 Sept 2010

Abstract excerpt

AZD6244 (ARRY-142886) is an inhibitor of MEK1/2 and can inhibit cell proliferation or induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of AZD6244-induced apoptosis is not clear. To investigate mechanisms of AZD6244 induced apoptosis in human lung cancer, we determined the molecular changes of two subgroups of human lung cancer cell lines that are either sensitive or resistant to...

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PMID: 20885957
DOI: 10.1371/journal.pone.0013026

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