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Article

Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activation.

Journal of lipid research - 1 Jan 2011

Weers Paul M M, Patel Arti B, Wan Leon C-P, Guigard Emmanuel, Kay Cyril M, Hafiane Anouar, McPherson Ruth, Marcel Yves L, Kiss Robert S

Abstract excerpt

We have identified a novel mutation in apoA-I (serine 36 to alanine; S36A) in a human subject with severe hypoalphalipoproteinemia. The mutation is located in the N-terminal region of the protein, which has been implicated in several functions, including lipid binding and lecithin:cholesterol acyltransferase (LCAT) activity. In the present study, the S36A protein was produced recombinantly and characterized both...

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Source

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Identifiers

PMID: 20884842
DOI: 10.1194/jlr.M007500
PMCID: PMC2999918

Genes

LCAT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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