Article
The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment.
Biochimica et biophysica acta - 1 Jan 2011
Tuuf Jessica, Kjellberg Matti A, Molotkovsky Julian G, Hanada Kentaro, Mattjus Peter
Abstract excerpt
The in vitro activity of the ceramide transporter, CERT has been studied using a fluorescence assay. CERT is responsible for the in vivo non-vesicular trafficking of ceramide between the endoplasmic reticulum and Golgi. In this study we have examined how the membrane environment surrounding the ceramide substrate, the membrane packing density and the membrane charge, are affecting the ceramide transfer activity....
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