Article
Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2010
Pirker Robert, Herth Felix J F, Kerr Keith M, Filipits Martin, Taron Miquel, Gandara David, Hirsch Fred R, Grunenwald Dominique, Popper Helmut, Smit Egbert, Dietel Manfred, Marchetti Antonio, Manegold Christian, Schirmacher Peter, Thomas Michael, Rosell Rafael, Cappuzzo Federico, Stahel Rolf
Abstract excerpt
INTRODUCTION: Activating somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor (EGFR) have recently been characterized in a subset of patients with advanced non-small cell lung cancer (NSCLC). Patients harboring these mutations in their tumors show excellent response to EGFR tyrosine kinase inhibitors (EGFR-TKIs). The EGFR-TKI gefitinib has been approved in Europe for the treatment...
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