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A Distinctive Subset of PEComas Harbors TFE3 Gene Fusions

21 Sept 2010

Abstract excerpt

Perivascular epithelioid cell neoplasms (PEComas) include the common renal angiomyolipoma, pulmonary clear cell sugar tumor, lymphangioleiomyomatosis, and less common neoplasms of soft tissue, gynecologic, and gastrointestinal tracts. Recently, aberrant immunoreactivity for TFE3 protein (a sensitive and specific marker of neoplasms harboring TFE3 gene fusions) has been reported in as many as 100% of PEComas;...

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PMID: 20871214
DOI: 10.1097/pas.0b013e3181f17ac0

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