Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.

FEBS letters - 22 Oct 2010

Liu Xiaojun, Qiao Aijun, Ke Yaojun, Kong Xingxing, Liang Jichao, Wang Rui, Ouyang Xiaoqing, Zuo Ji, Chang Yongsheng, Fang Fude

Abstract excerpt

Recent studies have demonstrated that FoxO1 modulates the expression of SREBP-1c, but the exact mechanism remains unknown. Our results demonstrate that FoxO1 suppresses the SREBP-1c promoter transcriptional activity in HepG2 cells. This repression was independent of FoxO1 binding to the SREBP-1c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Immunoprecipitation
Share to Cricetulus
Share to Forkhead Box Protein O1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Liver X Receptors

Share to Orphan Nuclear Receptors

Share to Response Elements

Share to Sterol Regulatory Element Binding Protein 1

Source

Identifiers

PMID: 20868688
DOI: 10.1016/j.febslet.2010.09.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20868688-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.PMID 20868688Read ↗

SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional ComplexSemantic proximity Read ↗

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic GenesSemantic proximity Read ↗

Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha).Semantic proximity Read ↗

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.Semantic proximity Read ↗

Transcriptional Analysis of FOXO1, C/EBP-α and PPAR-γ2 Genes and Their Association with Obesity-Related Insulin ResistanceSemantic proximity Read ↗

FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes.Semantic proximity Read ↗

Characterization of insulin inhibition of transactivation by a C-terminal fragment of the forkhead transcription factor Foxo1 in rat hepatoma cells.Semantic proximity Read ↗

SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expression in Vivo and in Vitro through a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoterSemantic proximity Read ↗

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.Semantic proximity Read ↗

Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes.Semantic proximity Read ↗

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle CellsSemantic proximity Read ↗

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.