Article
DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers.
Histochemistry and cell biology - 1 Oct 2010
Shen Tiansheng, Liu Yewei, Contreras Minerva, Hernández-Ochoa Erick O, Randall William R, Schneider Martin F
Abstract excerpt
We have previously demonstrated that Ca²+/calcineurin-dependent dephosphorylation of the transcription factor nuclear factor of activated T cells subtype 1 (NFATc1) during repetitive skeletal muscle activity causes NFAT nuclear translocation and concentration in subnuclear NFAT foci. We now show that NFAT nuclear foci colocalize with heterochromatin regions of intense staining by DAPI or TO-PRO-3 that are present...
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