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Article

Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.

Arthritis research & therapy - 1 Jan 2010

Eyre Stephen, Hinks Anne, Bowes John, Flynn Edward, Martin Paul, Wilson Anthony G, Morgan Ann W, Emery Paul, Steer Sophia, Hocking Lynne J, Reid David M, Harrison Pille, Wordsworth Paul, Thomson Wendy, Worthington Jane, Barton Anne

Abstract excerpt

INTRODUCTION: Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now well established that some of these loci are shared between diseases with similar aetiology. For example, a number of autoimmune diseases have been associated with variants in the PTPN22,...

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Topics

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Share to Arthritis, Rheumatoid
Share to Celiac Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genetic Predisposition to Disease

Share to Genotype

Share to GTPase-Activating Proteins

Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 20854658
DOI: 10.1186/ar3139
PMCID: PMC2991006

Genes

TAGAP
CTLA4
PTPN22
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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