Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency.

Stem cells and development - 1 Jun 2011

Vicente López María A, Vázquez García Miriam N, Entrena Ana, Olmedillas Lopez Susana, García-Arranz Mariano, García-Olmo Damián, Zapata Agustin

Abstract excerpt

Mesenchymal stem cells (MSCs) have emerged as important tools for cell therapy; therefore, identification of factors capable of governing their ex vivo expansion become essential. In this study we demonstrate that human adipose-derived stem cells (ASCs) express all components of the bone morphogenetic protein (BMP)/BMP receptor signaling pathway and respond to BMP4 inducing upregulated expression of its specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Bone Morphogenetic Protein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 4

Share to Cell Proliferation

Share to Cell Survival

Share to Culture Media, Serum-Free

Share to Multipotent Stem Cells

Share to Osteogenesis

Source

Identifiers

PMID: 20846028
DOI: 10.1089/scd.2010.0355

Genes

BMP4
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency.PMID 20846028Read ↗

Cell culture density affects the stemness gene expression of adipose tissue-derived mesenchymal stem cellsSemantic proximity Read ↗

Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease.Semantic proximity Read ↗

Regulation of ADSC Osteoinductive Potential Using Notch Pathway Inhibition and Gene Rescue: A Potential On/Off Switch for Clinical Applications in Bone Formation and Reconstructive EffortsSemantic proximity Read ↗

Osteogenic differentiation of stem cells alters vitamin D receptor expression.Semantic proximity Read ↗

Isolation and characterization of canine adipose-derived mesenchymal stem cells.Semantic proximity Read ↗

Importance of Sox2 in maintenance of cell proliferation and multipotency of mesenchymal stem cells in low-density culture.Semantic proximity Read ↗

Effects of Epidermal Growth Factor and Basic Fibroblast Growth Factor on the Proliferation and Osteogenic and Neural Differentiation of Adipose-Derived Stem CellsSemantic proximity Read ↗

Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signalingSemantic proximity Read ↗

FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells.Semantic proximity Read ↗

Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes.Semantic proximity Read ↗

Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics.Semantic proximity Read ↗

Dexamethasone treatment during the expansion phase maintains stemness of bone marrow mesenchymal stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.