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Relationship of EMAST and Microsatellite Instability Among Patients with Rectal Cancer

15 Sept 2010

Abstract excerpt

BACKGROUND: Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is a genetic signature identified in 60% of sporadic colon cancers and may be linked with heterogeneous expression of the DNA mismatch repair (MMR) protein hMSH3. Unlike microsatellite instability-high (MSI-H) in which hypermethylation of hMLH1 occurs followed by multiple susceptible gene mutations, EMAST may be associated...

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PMID: 20844976
DOI: 10.1007/s11605-010-1340-6

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