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Article

[Promoter hypermethylation and CpG island methylator phenotype in colorectal carcinogenesis].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Sept 2010

Matsubara Nagahide

Abstract excerpt

Amino acid alterations or insufficient protein synthesis caused by the mutation on genes has long been recognized as the main mechanism of silencing of suppressor genes leading to carcinogenesis. However, epigenetic silencing of the cancer related genes induced by hyper-methylation of promoter is recognized as an additional important molecular mechanism for carcinogenesis. Differing molecular mechanisms of...

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Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 20841928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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