p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.

doi:10.1016/j.bbagen.2010.09.002

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p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.

Biochimica et biophysica acta - 1 Dec 2010

Laska Magdalena J, Vogel Ulla B, Jensen Uffe B, Nexø Bjørn A

Abstract excerpt

BACKGROUND: PPP1R13L gene has been found to be over-expressed in variety of cancers and its expression in p53 wild-type background is sufficient to promote tumor growth in vivo. However, in the non-transformed cells it acts as a tumor suppressor which suggests that the role of PPP1R13L is multifaceted. METHODS: We have used siRNA optimized for inhibition of p53, PPP1R13L, BAX and GADD45 alpha expression and...

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p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.

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