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Article

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

29 Apr 2010

Abstract excerpt

BACKGROUND: Autophagy is characterized by the sequestration of cytoplasm and organelles into multimembrane vesicles and subsequent degradation by the cell's lysosomal system. It is linked to many physiological functions in human cells including stress response, protein degradation, organelle turnover, caspase-independent cell death and tumor suppression. Malignant transformation is frequently associated with...

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PMID: 20429933
DOI: 10.1186/1476-4598-9-95

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