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Article

Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 2010

Gearhart Patricia M, Gearhart Chris, Thompson Debra A, Petersen-Jones Simon M

Abstract excerpt

OBJECTIVE: To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs. METHODS: Intravitreal injection of 9-cis-retinal was administered in 1 eye of 7 Rpe65-/- dogs at a range of ages. Electroretinogram analysis and testing of visual performance was used to evaluate outcomes after a single injection and in 2 dogs after a second injection in the same...

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Identifiers

PMID: 20837787
DOI: 10.1001/archophthalmol.2010.210

Genes

RPE65

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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