Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.

doi:10.1001/archophthalmol.2010.210

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Article

Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 2010

Gearhart Patricia M, Gearhart Chris, Thompson Debra A, Petersen-Jones Simon M

Abstract excerpt

OBJECTIVE: To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs. METHODS: Intravitreal injection of 9-cis-retinal was administered in 1 eye of 7 Rpe65-/- dogs at a range of ages. Electroretinogram analysis and testing of visual performance was used to evaluate outcomes after a single injection and in 2 dogs after a second injection in the same...

Topics

Animals
Carrier Proteins
Dark Adaptation
Disease Models, Animal
Diterpenes
Dogs
Electroretinography
Eye Proteins
Female
Intravitreal Injections
Isomerism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leber Congenital Amaurosis

Male

Mutation

Photoreceptor Cells, Vertebrate

Retinaldehyde

Retreatment

Vision, Ocular

Source

Open in PubMed

Identifiers

PMID: 20837787
DOI: 10.1001/archophthalmol.2010.210

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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