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Article

Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6.

The Journal of biological chemistry - 12 Nov 2010

Into Takeshi, Inomata Megumi, Niida Shumpei, Murakami Yukitaka, Shibata Ken-ichiro

Abstract excerpt

MyD88 is an essential adaptor molecule for Toll-like receptors (TLRs) and interleukin (IL)-1 receptor. MyD88 is thought to be present as condensed forms or aggregated structures in the cytoplasm, although the reason has not yet been clear. Here, we show that endogenous MyD88 is present as small s...

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Share to Histone Deacetylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20837465
DOI: 10.1074/jbc.M110.126904
PMCID: PMC2975200

Genes

HDAC6
SQSTM1
TRAF6
CYLD
NOS2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20837465-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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