Interindividual variability in the enantiomeric disposition of ibuprofen following the oral administration of the racemic drug to healthy volunteers.

Abstract excerpt

The plasma disposition of the enantiomers of ibuprofen has been investigated following the oral administration of the racemic drug (400 mg) to 24 healthy male volunteers. The plasma elimination of (R)-ibuprofen was found to be more rapid than that of the S-enantiomer [plasma half-life: (R) 2.03 h; (S) 3.05 h; 2P less than 0.001], resulting in a progressive enrichment in the plasma content of this isomer, some 64%...

Topics

• Administration, Oral
• Adult
• Genetic Variation
• Humans
• Ibuprofen
• Male
• Metabolic Clearance Rate
• Reference Values
• Stereoisomerism
• Structure-Activity Relationship