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Variations of the CAG trinucleotide repeat in DNA polymerase γ (POLG1) is associated with Parkinson's disease in Sweden.

Neuroscience letters - 19 Nov 2010

Anvret Anna, Westerlund Marie, Sydow Olof, Willows Thomas, Lind Charlotta, Galter Dagmar, Belin Andrea Carmine

Abstract excerpt

DNA polymerase gamma (POLG1) is coding for the catalytic subunit of the heterotrimeric mitochondrial DNA polymerase and involved in replication and repair of mitochondrial DNA. In addition to its 5' to 3' polymerase activity, POLG1 has a 3' to 5' exonuclease activity important in the repair process. Mitochondrial dysfunction has been implicated in neurodegenerative disorders like Parkinson's disease (PD)....

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Identifiers

PMID: 20826197
DOI: 10.1016/j.neulet.2010.08.082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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