Article
HESX1: a novel gene implicated in a familial form of septo-optic dysplasia.
Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Dec 1999
Dattani M T, Martinez-Barbera J P, Thomas P Q, Brickman J M, Gupta R, Wales J K, Hindmarsh P C, Beddington R S, Robinson I C
Abstract excerpt
The homeobox gene Hesx1, which encodes a pituitary transcription factor, is first expressed at gastrulation in the mouse embryo. Hesx1 expression begins in prospective forebrain tissue but later becomes restricted to Rathke's pouch, the primordium of the anterior pituitary gland. Transgenic mice lacking Hesx1 exhibit a phenotype comprising variable anterior CNS defects, such as a reduced prosencephalon,...
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