Article
Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA.
RNA (New York, N.Y.) - 1 Nov 2010
Xiao Gaoping, Wesolowski Donna, Izadjoo Mina, Altman Sidney
Abstract excerpt
RNase P from E. coli will cleave a RNA at a site designated in a complex with an external guide sequence (EGS). The location of the site is determined by the Watson-Crick complementary sequence that can be formed between the RNA and the EGS. Morpholino oligonucleotides (PMOs) that have the same base sequences as any particular EGS will not direct cleavage by RNase P of the target RNA at the expected site in three...
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