Article
Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury.
Journal of neurotrauma - 1 Nov 2010
Harel Noam Y, Song Kang-Ho, Tang Xin, Strittmatter Stephen M
Abstract excerpt
We tested the ability of two plasticity-promoting approaches to enhance recovery in a mouse model of incomplete spinal cord injury (SCI). Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm. Adult mice of wild-type or NgR-null genotype were subjected to partial lateral...
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