Article

An Adeno-Associated Viral vector encoding Neurotrophin 3 injected into affected forelimb muscles modestly improves sensorimotor function after contusive mid-cervical spinal cord injury

2021-02-25

Abstract excerpt

Traumatic spinal cord injury (SCI) in humans occurs most frequently in the cervical spine where it can cause substantial sensorimotor impairments to upper limb function. The altered input to spinal circuits below the lesion leads to maladaptive reorganisation which often leads to hyperreflexia in proprioceptive circuits. Neurotrophin 3 (NT3) is growth factor essential for the development of proprioceptive neurons....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec700442-a34c-5d81-8b7b-19ad1df630ba
DOI: 10.1101/2021.02.24.432676

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Adeno-Associated Viral vector encoding Neurotrophin 3 injected into affected forelimb muscles modestly improves sensorimotor function after contusive mid-cervical spinal cord injuryDOI 10.1101/2021.02.24.432676Read

Corticospinal neuroplasticity and sensorimotor recovery in rats treated by infusion of neurotrophin-3 into disabled forelimb muscles started 24 h after strokeSemantic proximity Read

RNAseq dataset describing transcriptional changes in cervical sensory ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with AAV1 encoding human neurotrophin-3Semantic proximity Read

TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.Semantic proximity Read

Pre-Injury Mechanoreceptor Ablation Reduces Nociceptor-Driven Spinal Cord Injury-Induced Neuropathic PainSemantic proximity Read

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injurySemantic proximity Read

Upper Limb Robotic Rehabilitation for Patients With Cervical Spinal Cord Injury: A Comprehensive ReviewSemantic proximity Read

MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repairSemantic proximity Read

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb FunctionSemantic proximity Read

At-level allodynia after mid-thoracic contusion in the ratSemantic proximity Read

Clinical efficacy analysis of the treatment of central hemiplegia with cervical nerve 7 displacement via anterior cervical approach under microscopeSemantic proximity Read

Botulinum toxin as adjuvant therapy for hypertonic dysfunction in a neuro-rehabilitation cohortSemantic proximity Read

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read