Article
Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.
PloS one - 19 Aug 2010
Rückert Felix, Dawelbait Gihan, Winter Christof, Hartmann Arndt, Denz Axel, Ammerpohl Ole, Schroeder Michael, Schackert Hans Konrad, Sipos Bence, Klöppel Günter, Kalthoff Holger, Saeger Hans-Detlev, Pilarsky Christian, Grützmann Robert
Abstract excerpt
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer death. Changes in apoptosis signaling in pancreatic cancer result in chemotherapy resistance and aggressive growth and metastasizing. The aim of this study was to characterize the apoptosis pathway in pancreatic cancer computationally by evaluation of experimental data from high-throughput technologies and public data bases....
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