Article
Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome.
European journal of human genetics : EJHG - 1 Feb 2011
Krumbiegel Mandy, Pasutto Francesca, Schlötzer-Schrehardt Ursula, Uebe Steffen, Zenkel Matthias, Mardin Christian Y, Weisschuh Nicole, Paoli Daniela, Gramer Eugen, Becker Christian, Ekici Arif B, Weber Bernhard H F, Nürnberg Peter, Kruse Friedrich E, Reis André
Abstract excerpt
Genetic and nongenetic factors contribute to development of pseudoexfoliation (PEX) syndrome, a complex, age-related, generalized matrix process frequently associated with glaucoma. To identify specific genetic variants underlying its etiology, we performed a genome-wide association study (GWAS) using a DNA-pooling approach. Therefore, equimolar amounts of DNA samples of 80 subjects with PEX syndrome, 80 with PEX...
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