Article
Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy.
Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2010
Pattani Kavita Malhotra, Zhang Zhe, Demokan Semra, Glazer Chad, Loyo Myriam, Goodman Steven, Sidransky David, Bermudez Francisco, Jean-Charles Germain, McCaffrey Thomas, Padhya Tapan, Phelan Joan, Spivakovsky Silvia, Bowne Helen Yoo, Goldberg Judith D, Rolnitzky Linda, Robbins Miriam, Kerr A Ross, Sirois David, Califano Joseph A
Abstract excerpt
Endothelin receptor type B (EDNRB) and kinesin family member 1A (KIF1A) are candidate tumor suppressor genes that are inactivated in cancers. In this study, we evaluated the promoter hypermethylation of EDNRB and KIF1A and their potential use for risk classification in prospectively collected salivary rinses from patients with premalignant/malignant oral cavity lesions. Quantitative methylation-specific PCR was...
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