Autosomal dominant polycystic kidney disease and mTOR inhibitors: the narrow road between hope and disappointment

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease characterized by the development of innumerable cysts in the kidneys and progressive renal dysfunction eventually leading to end-stage renal disease. In a number of cases, cysts can develop also in the liver and in the pancreas. Inheritance is autosomal dominant and is caused by single-dose mutations of either the gene PKD1 in chromosome...

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