Article
Extrachromosomal resistance in gram-negative organisms: the evolution of beta-lactamase.
Trends in microbiology - 1 Oct 1994
Jacoby G A
Abstract excerpt
beta-Lactamases are the major defense used by bacteria to overcome the effects of penicillins, cephalosporins and related beta-lactam antibiotics. In the antibiotic era, the enzymes have evolved to become more prevalent, to appear in new hosts, to be expressed at higher levels, to be acquired by plasmids and to change catalytic properties to increase affinity for what were meant to be nonhydrolysable substrates...
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