Extrachromosomal resistance in gram-negative organisms: the evolution of beta-lactamase.

doi:10.1016/0966-842x(94)90611-4

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Article

Extrachromosomal resistance in gram-negative organisms: the evolution of beta-lactamase.

Trends in microbiology - 1 Oct 1994

Jacoby G A

Abstract excerpt

beta-Lactamases are the major defense used by bacteria to overcome the effects of penicillins, cephalosporins and related beta-lactam antibiotics. In the antibiotic era, the enzymes have evolved to become more prevalent, to appear in new hosts, to be expressed at higher levels, to be acquired by...

Topics

Genes, Bacterial
Gram-Negative Bacteria
Mutation
Plasmids
beta-Lactam Resistance
beta-Lactamases

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