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Article

Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer

29 Aug 2010

Abstract excerpt

Squamous cell carcinoma (SCC) of the vulva is a heterogeneous disease, associated or not with vulvar lichen sclerosus (LS). The precursor role of LS in vulvar cancer is unclear. We studied the epigenetic alterations of RASSF1A, RASSF2A, p16, TSP-1 and MGMT genes in vulvar SCCs, LS associated with SCC, isolated LS and normal vulvar skin. Gene hypermethylation and human papillomavirus presence were evaluated by...

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PMID: 20734389
DOI: 10.1002/ijc.25629

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