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Article

Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.

Dementia and geriatric cognitive disorders - 1 Jan 2010

Gold Michael, Alderton Claire, Zvartau-Hind Marina, Egginton Sally, Saunders Ann M, Irizarry Michael, Craft Suzanne, Landreth Gary, Linnamägi Ulla, Sawchak Sharon

Abstract excerpt

BACKGROUND/AIMS: A phase II study of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone extended release (RSG XR) in mild-to-moderate Alzheimer's disease (AD) detected a treatment benefit to cognition in apolipoprotein E(APOE)-ε4-negative subjects. The current phase III study with prospective stratification by APOE genotype was conducted to confirm the efficacy and safety of RSG XR in...

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Identifiers

PMID: 20733306
DOI: 10.1159/000318845
PMCID: PMC3214882

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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