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Article

Structures of mouse SOD1 and human/mouse SOD1 chimeras.

Archives of biochemistry and biophysics - 15 Nov 2010

Seetharaman Sai V, Taylor Alexander B, Holloway Stephen, Hart P John

Abstract excerpt

Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherited form of amyotrophic lateral sclerosis (ALS). Inclusions enriched in pathogenic SOD1 accumulate in the spinal cords of transgenic mice expressing these proteins, but endogenous mouse SOD1 is not found as a component of these aggregates. In the accompanying paper, Karch and colleagues analyze aggregation propensities of human/mouse SOD1...

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Identifiers

PMID: 20727846
DOI: 10.1016/j.abb.2010.08.014
PMCID: PMC3037271

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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