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Article

Aggregation modulating elements in mutant human superoxide dismutase 1.

Archives of biochemistry and biophysics - 15 Nov 2010

Karch Celeste M, Borchelt David R

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) cause some forms of familial amyotrophic lateral sclerosis (fALS). Affected tissues of patients and transgenic mouse models of the disease accumulate misfolded and aggregated forms of the mutant protein. In the present study we have identified specific sequences in human SOD1 that modulate the aggregation of fALS mutant proteins. From our study of a panel of mutant...

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Identifiers

PMID: 20682279
DOI: 10.1016/j.abb.2010.07.027
PMCID: PMC2997613

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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